{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:ZA7FNKJZYN7QE2RWAI2JVVNQ4I","short_pith_number":"pith:ZA7FNKJZ","canonical_record":{"source":{"id":"2508.15163","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2025-08-21T02:01:49Z","cross_cats_sorted":[],"title_canon_sha256":"f03575e582ab6875da0d6d64e7b5546f03ba934b4f833dd97f46a33e5d87a7e0","abstract_canon_sha256":"bd8c08d5b638de0bc5e756153986274fe667e45f1f2db1a43097df2a97b364f7"},"schema_version":"1.0"},"canonical_sha256":"c83e56a939c37f026a3602349ad5b0e204407fed20b569f6198f9a73fd679be9","source":{"kind":"arxiv","id":"2508.15163","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.15163","created_at":"2026-07-05T11:57:07Z"},{"alias_kind":"arxiv_version","alias_value":"2508.15163v1","created_at":"2026-07-05T11:57:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.15163","created_at":"2026-07-05T11:57:07Z"},{"alias_kind":"pith_short_12","alias_value":"ZA7FNKJZYN7Q","created_at":"2026-07-05T11:57:07Z"},{"alias_kind":"pith_short_16","alias_value":"ZA7FNKJZYN7QE2RW","created_at":"2026-07-05T11:57:07Z"},{"alias_kind":"pith_short_8","alias_value":"ZA7FNKJZ","created_at":"2026-07-05T11:57:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:ZA7FNKJZYN7QE2RWAI2JVVNQ4I","target":"record","payload":{"canonical_record":{"source":{"id":"2508.15163","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2025-08-21T02:01:49Z","cross_cats_sorted":[],"title_canon_sha256":"f03575e582ab6875da0d6d64e7b5546f03ba934b4f833dd97f46a33e5d87a7e0","abstract_canon_sha256":"bd8c08d5b638de0bc5e756153986274fe667e45f1f2db1a43097df2a97b364f7"},"schema_version":"1.0"},"canonical_sha256":"c83e56a939c37f026a3602349ad5b0e204407fed20b569f6198f9a73fd679be9","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:57:07.407440Z","signature_b64":"mtxv0n3UOljQGJKFUyB+esl89YkTKMSEG82wC5ey9CbugTQ2J9VY9et04LpvAO8hXT6/NMaK2y0PUyWvrXP8Dg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"c83e56a939c37f026a3602349ad5b0e204407fed20b569f6198f9a73fd679be9","last_reissued_at":"2026-07-05T11:57:07.406979Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:57:07.406979Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2508.15163","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:57:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"7xwQSPwVC/3IY1HRJzY7vfe7ME/mpLzOm6+edwvPQ4SR9JNMv41eGdJsEmWLU0vfrzTbtCivAABM2wiy0ZUVAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T08:46:46.310378Z"},"content_sha256":"035dd8bab51cc3358183d748d5a77254f3aebd4804806fc7c97495a731341a41","schema_version":"1.0","event_id":"sha256:035dd8bab51cc3358183d748d5a77254f3aebd4804806fc7c97495a731341a41"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:ZA7FNKJZYN7QE2RWAI2JVVNQ4I","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Non-invasive Assessment of Pancreatic Duct Hypertension Using Computational Flow Modeling","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Haobo Zhao, Jung-Hee Seo, Rajat Mittal, Surya Evani, Venkata Akshintala","submitted_at":"2025-08-21T02:01:49Z","abstract_excerpt":"Chronic pancreatitis (CP) is a progressive inflammatory disease frequently associated with severe, treatment-resistant abdominal pain, which is hypothesized to result from pancreatic ductal hypertension (PDH) secondary to ductal strictures or obstructions. However, direct measurement of pancreatic duct pressure (PDP) remains technically demanding and invasive, thereby significantly limiting its routine clinical application. Here, we propose and validate a novel, non-invasive approach for estimating PDP. The method integrates patient-specific magnetic resonance cholangiopancreatography (MRCP) i"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.15163","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2508.15163/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:57:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"j4u5LHZn1Brv821smC8aaOisZtjFszE537U/ei1Ek7wk6wEbrL0hP1zgUfr8TisD1w254wZL+7jo+IB9dcG5BQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T08:46:46.310892Z"},"content_sha256":"a1d961dff00cdbcbba74d7be7117058ccf747d362b22cece68e2add13c7e4f14","schema_version":"1.0","event_id":"sha256:a1d961dff00cdbcbba74d7be7117058ccf747d362b22cece68e2add13c7e4f14"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ZA7FNKJZYN7QE2RWAI2JVVNQ4I/bundle.json","state_url":"https://pith.science/pith/ZA7FNKJZYN7QE2RWAI2JVVNQ4I/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ZA7FNKJZYN7QE2RWAI2JVVNQ4I/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-06T08:46:46Z","links":{"resolver":"https://pith.science/pith/ZA7FNKJZYN7QE2RWAI2JVVNQ4I","bundle":"https://pith.science/pith/ZA7FNKJZYN7QE2RWAI2JVVNQ4I/bundle.json","state":"https://pith.science/pith/ZA7FNKJZYN7QE2RWAI2JVVNQ4I/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ZA7FNKJZYN7QE2RWAI2JVVNQ4I/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:ZA7FNKJZYN7QE2RWAI2JVVNQ4I","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"bd8c08d5b638de0bc5e756153986274fe667e45f1f2db1a43097df2a97b364f7","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2025-08-21T02:01:49Z","title_canon_sha256":"f03575e582ab6875da0d6d64e7b5546f03ba934b4f833dd97f46a33e5d87a7e0"},"schema_version":"1.0","source":{"id":"2508.15163","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.15163","created_at":"2026-07-05T11:57:07Z"},{"alias_kind":"arxiv_version","alias_value":"2508.15163v1","created_at":"2026-07-05T11:57:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.15163","created_at":"2026-07-05T11:57:07Z"},{"alias_kind":"pith_short_12","alias_value":"ZA7FNKJZYN7Q","created_at":"2026-07-05T11:57:07Z"},{"alias_kind":"pith_short_16","alias_value":"ZA7FNKJZYN7QE2RW","created_at":"2026-07-05T11:57:07Z"},{"alias_kind":"pith_short_8","alias_value":"ZA7FNKJZ","created_at":"2026-07-05T11:57:07Z"}],"graph_snapshots":[{"event_id":"sha256:a1d961dff00cdbcbba74d7be7117058ccf747d362b22cece68e2add13c7e4f14","target":"graph","created_at":"2026-07-05T11:57:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2508.15163/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Chronic pancreatitis (CP) is a progressive inflammatory disease frequently associated with severe, treatment-resistant abdominal pain, which is hypothesized to result from pancreatic ductal hypertension (PDH) secondary to ductal strictures or obstructions. However, direct measurement of pancreatic duct pressure (PDP) remains technically demanding and invasive, thereby significantly limiting its routine clinical application. Here, we propose and validate a novel, non-invasive approach for estimating PDP. The method integrates patient-specific magnetic resonance cholangiopancreatography (MRCP) i","authors_text":"Haobo Zhao, Jung-Hee Seo, Rajat Mittal, Surya Evani, Venkata Akshintala","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2025-08-21T02:01:49Z","title":"Non-invasive Assessment of Pancreatic Duct Hypertension Using Computational Flow Modeling"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.15163","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:035dd8bab51cc3358183d748d5a77254f3aebd4804806fc7c97495a731341a41","target":"record","created_at":"2026-07-05T11:57:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"bd8c08d5b638de0bc5e756153986274fe667e45f1f2db1a43097df2a97b364f7","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2025-08-21T02:01:49Z","title_canon_sha256":"f03575e582ab6875da0d6d64e7b5546f03ba934b4f833dd97f46a33e5d87a7e0"},"schema_version":"1.0","source":{"id":"2508.15163","kind":"arxiv","version":1}},"canonical_sha256":"c83e56a939c37f026a3602349ad5b0e204407fed20b569f6198f9a73fd679be9","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"c83e56a939c37f026a3602349ad5b0e204407fed20b569f6198f9a73fd679be9","first_computed_at":"2026-07-05T11:57:07.406979Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:57:07.406979Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"mtxv0n3UOljQGJKFUyB+esl89YkTKMSEG82wC5ey9CbugTQ2J9VY9et04LpvAO8hXT6/NMaK2y0PUyWvrXP8Dg==","signature_status":"signed_v1","signed_at":"2026-07-05T11:57:07.407440Z","signed_message":"canonical_sha256_bytes"},"source_id":"2508.15163","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:035dd8bab51cc3358183d748d5a77254f3aebd4804806fc7c97495a731341a41","sha256:a1d961dff00cdbcbba74d7be7117058ccf747d362b22cece68e2add13c7e4f14"],"state_sha256":"8249e209211d2b0cc7178fc13bbf004a43233fb06311769561fb88ec33f603e6"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xfoge9JUbe4lMp2pzgIsoEvn+CMsamFw6BCLJRqUvTgKYJEymkITaWHRK7YTrq9OClKHL0rFm4sGKYzcizhADg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-06T08:46:46.315852Z","bundle_sha256":"4b4ee51090c5bc1e090821058ac9be33382daf97bc1cf158c47414ff17eb80a9"}}