{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2018:ZC6LNN22FLLQM7G77PTJL554WC","short_pith_number":"pith:ZC6LNN22","schema_version":"1.0","canonical_sha256":"c8bcb6b75a2ad7067cdffbe695f7bcb0ad7765f3c38b705ededbbdef4aba3ab0","source":{"kind":"arxiv","id":"1803.04500","version":2},"attestation_state":"computed","paper":{"title":"The hypotensive effect of activated apelin receptor is correlated with \\b{eta}-arrestin recruitment","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["q-bio.BM","q-bio.CB","q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"Alexandre Murza, \\'Elie Besserer-Offroy, \\'Eric Marsault, Jean-Michel Longpr\\'e, J\\'er\\^ome C\\^ot\\'e, Mannix Auger-Messier, Olivier Lesur, Patrick B\\'erub\\'e, Philippe Sarret, Richard Leduc, Robert Dumaine","submitted_at":"2018-03-12T20:01:06Z","abstract_excerpt":"The apelinergic system is an important player in the regulation of both vascular tone and cardiovascular function, making this physiological system an attractive target for drug development for hypertension, heart failure and ischemic heart disease. Indeed, apelin exerts a positive inotropic effect in humans whilst reducing peripheral vascular resistance. In this study, we investigated the signaling pathways through which apelin exerts its hypotensive action. We synthesized a series of apelin-13 analogs whereby the C-terminal Phe13 residue was replaced by natural or unnatural amino acids. In H"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1803.04500","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.MN","submitted_at":"2018-03-12T20:01:06Z","cross_cats_sorted":["q-bio.BM","q-bio.CB","q-bio.QM"],"title_canon_sha256":"4199cd2c7eb0945607fd7f70b351b0456bf56e74799f56b9094bfc8bb0333950","abstract_canon_sha256":"26a7cb7477494506af9d2231fe22c3b4d5eb52d2009d9fc9760540b67e3ff979"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:21:04.144521Z","signature_b64":"dWGs2GBfnZfWkU3N5r8Em7oaMyWq8BE22519c7v7YLSFrTJmeLz18LsXZqdLinaAJc73FXPP+bRrjIf4lGhICg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"c8bcb6b75a2ad7067cdffbe695f7bcb0ad7765f3c38b705ededbbdef4aba3ab0","last_reissued_at":"2026-05-18T00:21:04.143872Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:21:04.143872Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"The hypotensive effect of activated apelin receptor is correlated with \\b{eta}-arrestin recruitment","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["q-bio.BM","q-bio.CB","q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"Alexandre Murza, \\'Elie Besserer-Offroy, \\'Eric Marsault, Jean-Michel Longpr\\'e, J\\'er\\^ome C\\^ot\\'e, Mannix Auger-Messier, Olivier Lesur, Patrick B\\'erub\\'e, Philippe Sarret, Richard Leduc, Robert Dumaine","submitted_at":"2018-03-12T20:01:06Z","abstract_excerpt":"The apelinergic system is an important player in the regulation of both vascular tone and cardiovascular function, making this physiological system an attractive target for drug development for hypertension, heart failure and ischemic heart disease. Indeed, apelin exerts a positive inotropic effect in humans whilst reducing peripheral vascular resistance. In this study, we investigated the signaling pathways through which apelin exerts its hypotensive action. We synthesized a series of apelin-13 analogs whereby the C-terminal Phe13 residue was replaced by natural or unnatural amino acids. In H"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1803.04500","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1803.04500","created_at":"2026-05-18T00:21:04.143970+00:00"},{"alias_kind":"arxiv_version","alias_value":"1803.04500v2","created_at":"2026-05-18T00:21:04.143970+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1803.04500","created_at":"2026-05-18T00:21:04.143970+00:00"},{"alias_kind":"pith_short_12","alias_value":"ZC6LNN22FLLQ","created_at":"2026-05-18T12:33:04.347982+00:00"},{"alias_kind":"pith_short_16","alias_value":"ZC6LNN22FLLQM7G7","created_at":"2026-05-18T12:33:04.347982+00:00"},{"alias_kind":"pith_short_8","alias_value":"ZC6LNN22","created_at":"2026-05-18T12:33:04.347982+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/ZC6LNN22FLLQM7G77PTJL554WC","json":"https://pith.science/pith/ZC6LNN22FLLQM7G77PTJL554WC.json","graph_json":"https://pith.science/api/pith-number/ZC6LNN22FLLQM7G77PTJL554WC/graph.json","events_json":"https://pith.science/api/pith-number/ZC6LNN22FLLQM7G77PTJL554WC/events.json","paper":"https://pith.science/paper/ZC6LNN22"},"agent_actions":{"view_html":"https://pith.science/pith/ZC6LNN22FLLQM7G77PTJL554WC","download_json":"https://pith.science/pith/ZC6LNN22FLLQM7G77PTJL554WC.json","view_paper":"https://pith.science/paper/ZC6LNN22","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1803.04500&json=true","fetch_graph":"https://pith.science/api/pith-number/ZC6LNN22FLLQM7G77PTJL554WC/graph.json","fetch_events":"https://pith.science/api/pith-number/ZC6LNN22FLLQM7G77PTJL554WC/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/ZC6LNN22FLLQM7G77PTJL554WC/action/timestamp_anchor","attest_storage":"https://pith.science/pith/ZC6LNN22FLLQM7G77PTJL554WC/action/storage_attestation","attest_author":"https://pith.science/pith/ZC6LNN22FLLQM7G77PTJL554WC/action/author_attestation","sign_citation":"https://pith.science/pith/ZC6LNN22FLLQM7G77PTJL554WC/action/citation_signature","submit_replication":"https://pith.science/pith/ZC6LNN22FLLQM7G77PTJL554WC/action/replication_record"}},"created_at":"2026-05-18T00:21:04.143970+00:00","updated_at":"2026-05-18T00:21:04.143970+00:00"}