{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2017:ZF2MBRKQYP4TLEZM4FQ3BO7CDZ","short_pith_number":"pith:ZF2MBRKQ","schema_version":"1.0","canonical_sha256":"c974c0c550c3f935932ce161b0bbe21e4aac8414bae1737d75fe0c9aa2f449bc","source":{"kind":"arxiv","id":"1708.06579","version":1},"attestation_state":"computed","paper":{"title":"Effect of cell heterogeneity on isogenic populations with the synthetic genetic toggle switch network: bifurcation analysis of two-dimensional Cell Population Balance Models","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN"],"primary_cat":"q-bio.PE","authors_text":"Andreas G. Boudouvis, Michail E. Kavousanakis, Panagiotis Chrysinas","submitted_at":"2017-08-22T12:22:58Z","abstract_excerpt":"The dynamics of gene regulatory networks are often modeled with the assumption of cellular homogeneity. However, this assumption contradicts the plethora of experimental results in a variety of systems, which designates that cell populations are heterogeneous systems in the sense that properties such as size, shape, and DNA/RNA content are unevenly distributed amongst their individuals. In order to address the implications of heterogeneity, we utilize the so-called cell population balance (CPB) models. Here, we solve numerically multivariable CPB models to study the effect of heterogeneity on "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1708.06579","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2017-08-22T12:22:58Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"5f5766fa05913724ba596eaeb5c771dc6b7760ff5cb19eb10f2f2be6b8c1df97","abstract_canon_sha256":"32de1ac890f9d06b204cf258e26c851bbc8edaa170e7966ed4503d87e363365f"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:37:33.110434Z","signature_b64":"/w5lehxipAW4AHxtUYDgv0Xq6nYY5c4+W6DVubxujbNEw9dMWc7T4WFYnq1cEDEDR556VOuSDVdzNBPhexSUAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"c974c0c550c3f935932ce161b0bbe21e4aac8414bae1737d75fe0c9aa2f449bc","last_reissued_at":"2026-05-18T00:37:33.110049Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:37:33.110049Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Effect of cell heterogeneity on isogenic populations with the synthetic genetic toggle switch network: bifurcation analysis of two-dimensional Cell Population Balance Models","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN"],"primary_cat":"q-bio.PE","authors_text":"Andreas G. Boudouvis, Michail E. Kavousanakis, Panagiotis Chrysinas","submitted_at":"2017-08-22T12:22:58Z","abstract_excerpt":"The dynamics of gene regulatory networks are often modeled with the assumption of cellular homogeneity. However, this assumption contradicts the plethora of experimental results in a variety of systems, which designates that cell populations are heterogeneous systems in the sense that properties such as size, shape, and DNA/RNA content are unevenly distributed amongst their individuals. In order to address the implications of heterogeneity, we utilize the so-called cell population balance (CPB) models. Here, we solve numerically multivariable CPB models to study the effect of heterogeneity on "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1708.06579","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1708.06579","created_at":"2026-05-18T00:37:33.110106+00:00"},{"alias_kind":"arxiv_version","alias_value":"1708.06579v1","created_at":"2026-05-18T00:37:33.110106+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1708.06579","created_at":"2026-05-18T00:37:33.110106+00:00"},{"alias_kind":"pith_short_12","alias_value":"ZF2MBRKQYP4T","created_at":"2026-05-18T12:31:59.375834+00:00"},{"alias_kind":"pith_short_16","alias_value":"ZF2MBRKQYP4TLEZM","created_at":"2026-05-18T12:31:59.375834+00:00"},{"alias_kind":"pith_short_8","alias_value":"ZF2MBRKQ","created_at":"2026-05-18T12:31:59.375834+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ","json":"https://pith.science/pith/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ.json","graph_json":"https://pith.science/api/pith-number/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ/graph.json","events_json":"https://pith.science/api/pith-number/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ/events.json","paper":"https://pith.science/paper/ZF2MBRKQ"},"agent_actions":{"view_html":"https://pith.science/pith/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ","download_json":"https://pith.science/pith/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ.json","view_paper":"https://pith.science/paper/ZF2MBRKQ","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1708.06579&json=true","fetch_graph":"https://pith.science/api/pith-number/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ/graph.json","fetch_events":"https://pith.science/api/pith-number/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ/action/timestamp_anchor","attest_storage":"https://pith.science/pith/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ/action/storage_attestation","attest_author":"https://pith.science/pith/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ/action/author_attestation","sign_citation":"https://pith.science/pith/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ/action/citation_signature","submit_replication":"https://pith.science/pith/ZF2MBRKQYP4TLEZM4FQ3BO7CDZ/action/replication_record"}},"created_at":"2026-05-18T00:37:33.110106+00:00","updated_at":"2026-05-18T00:37:33.110106+00:00"}