{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:ZFLQXJD6H2W74J4KLCZ32FSEOD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f1dceaedde3c42ccdb6bd06510e0f0b45270a63d321b5b025c11bc97796a4ab0","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2015-02-17T08:32:19Z","title_canon_sha256":"fd5569d66309626a9eb8f5db6f5c5b1e629c87b4570aee05fd4de53d37f2c114"},"schema_version":"1.0","source":{"id":"1502.04826","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1502.04826","created_at":"2026-05-18T01:28:38Z"},{"alias_kind":"arxiv_version","alias_value":"1502.04826v2","created_at":"2026-05-18T01:28:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1502.04826","created_at":"2026-05-18T01:28:38Z"},{"alias_kind":"pith_short_12","alias_value":"ZFLQXJD6H2W7","created_at":"2026-05-18T12:29:52Z"},{"alias_kind":"pith_short_16","alias_value":"ZFLQXJD6H2W74J4K","created_at":"2026-05-18T12:29:52Z"},{"alias_kind":"pith_short_8","alias_value":"ZFLQXJD6","created_at":"2026-05-18T12:29:52Z"}],"graph_snapshots":[{"event_id":"sha256:21506c25161c4d201bf7dd8e791778498d2790b17145ab069143526a7e7b9470","target":"graph","created_at":"2026-05-18T01:28:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident light was systematically controlled using a spatial light modulator in order to overcome multiple light-scattering in a mouse skull layer and to focus light on the target cells. We demonstrate that illumination with shaped waves enables spatiotemporal regulation of intracellular Ca2+ level at the individual-cell level.","authors_text":"Chulhee Choi, Jin Man Kim, Jongchan Park, Jonghee Yoon, KyeoReh Lee, Minji Lee, Nury Kim, Won Do Heo, YongKeun Park","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2015-02-17T08:32:19Z","title":"Optogenetic control of cell signaling pathway through scattering skull using wavefront shaping"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1502.04826","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:147a091f4fcf3e44ee73e8123f5a50ee63e9414166f08bcfbca97570f8b35725","target":"record","created_at":"2026-05-18T01:28:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f1dceaedde3c42ccdb6bd06510e0f0b45270a63d321b5b025c11bc97796a4ab0","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2015-02-17T08:32:19Z","title_canon_sha256":"fd5569d66309626a9eb8f5db6f5c5b1e629c87b4570aee05fd4de53d37f2c114"},"schema_version":"1.0","source":{"id":"1502.04826","kind":"arxiv","version":2}},"canonical_sha256":"c9570ba47e3eadfe278a58b3bd164470e05af27c82595bc8a44e34750a203534","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"c9570ba47e3eadfe278a58b3bd164470e05af27c82595bc8a44e34750a203534","first_computed_at":"2026-05-18T01:28:38.740135Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:28:38.740135Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"+Mkyj/NS3B4J5cSL1NzKDr/JAzQndm65knwDp8SwqnCUJDcEEVY5nmQEyjDyMmCVBFecbnYyISI66bV82GKGDw==","signature_status":"signed_v1","signed_at":"2026-05-18T01:28:38.740606Z","signed_message":"canonical_sha256_bytes"},"source_id":"1502.04826","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:147a091f4fcf3e44ee73e8123f5a50ee63e9414166f08bcfbca97570f8b35725","sha256:21506c25161c4d201bf7dd8e791778498d2790b17145ab069143526a7e7b9470"],"state_sha256":"50fde957509fae7d8039df15139de9cf566782ed4233e36feccbe3b4aad979b2"}