{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:ZQOQ32ZUVK23JOQWMJYVTCUVCY","short_pith_number":"pith:ZQOQ32ZU","canonical_record":{"source":{"id":"2109.01854","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"eess.IV","submitted_at":"2021-09-04T12:19:33Z","cross_cats_sorted":["cs.CV","q-bio.NC"],"title_canon_sha256":"6e1bd7ee50120708893b0c935bd164eb37c9bfb91cee39126f26ef5b71b7594c","abstract_canon_sha256":"cb74e93a6ee4fc8f63ab26eaba1e14887f1b2f18fc697db6c3fd3d2c2120247d"},"schema_version":"1.0"},"canonical_sha256":"cc1d0deb34aab5b4ba166271598a951609e7b52f4f1ee4ecebc8527c9d4f943b","source":{"kind":"arxiv","id":"2109.01854","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2109.01854","created_at":"2026-07-05T03:13:05Z"},{"alias_kind":"arxiv_version","alias_value":"2109.01854v2","created_at":"2026-07-05T03:13:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2109.01854","created_at":"2026-07-05T03:13:05Z"},{"alias_kind":"pith_short_12","alias_value":"ZQOQ32ZUVK23","created_at":"2026-07-05T03:13:05Z"},{"alias_kind":"pith_short_16","alias_value":"ZQOQ32ZUVK23JOQW","created_at":"2026-07-05T03:13:05Z"},{"alias_kind":"pith_short_8","alias_value":"ZQOQ32ZU","created_at":"2026-07-05T03:13:05Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:ZQOQ32ZUVK23JOQWMJYVTCUVCY","target":"record","payload":{"canonical_record":{"source":{"id":"2109.01854","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"eess.IV","submitted_at":"2021-09-04T12:19:33Z","cross_cats_sorted":["cs.CV","q-bio.NC"],"title_canon_sha256":"6e1bd7ee50120708893b0c935bd164eb37c9bfb91cee39126f26ef5b71b7594c","abstract_canon_sha256":"cb74e93a6ee4fc8f63ab26eaba1e14887f1b2f18fc697db6c3fd3d2c2120247d"},"schema_version":"1.0"},"canonical_sha256":"cc1d0deb34aab5b4ba166271598a951609e7b52f4f1ee4ecebc8527c9d4f943b","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:13:05.892479Z","signature_b64":"Ri/3StTIo0eRYhvI4ByJAnUP+s5DpSxkbHFeJPGZBa97HMMu1sfefUVhR3NP/bj3lnc3cqRqQuvsMP0PKSkMAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"cc1d0deb34aab5b4ba166271598a951609e7b52f4f1ee4ecebc8527c9d4f943b","last_reissued_at":"2026-07-05T03:13:05.892018Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:13:05.892018Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2109.01854","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:13:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"F7bAxOeqVLJSSbOSI9apNuumuUHI2CvE66ORX5fBSLkr5Hg+iT/ECsYPZaT5ZamfwMDTOMm/XQBzPDt/RVuFAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-17T11:09:58.211889Z"},"content_sha256":"e5f2c1f4754d4d38210900c5520526a7cf7636640bddadb28cb16bc4853d4fa9","schema_version":"1.0","event_id":"sha256:e5f2c1f4754d4d38210900c5520526a7cf7636640bddadb28cb16bc4853d4fa9"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:ZQOQ32ZUVK23JOQWMJYVTCUVCY","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Predicting isocitrate dehydrogenase mutation status in glioma using structural brain networks and graph neural networks","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["cs.CV","q-bio.NC"],"primary_cat":"eess.IV","authors_text":"Carola-Bibiane Sch\\\"onlieb, Chao Li, Stephen J. Price, Xi Chen, Yiran Wei, Yonghao Li","submitted_at":"2021-09-04T12:19:33Z","abstract_excerpt":"Glioma is a common malignant brain tumor with distinct survival among patients. The isocitrate dehydrogenase (IDH) gene mutation provides critical diagnostic and prognostic value for glioma. It is of crucial significance to non-invasively predict IDH mutation based on pre-treatment MRI. Machine learning/deep learning models show reasonable performance in predicting IDH mutation using MRI. However, most models neglect the systematic brain alterations caused by tumor invasion, where widespread infiltration along white matter tracts is a hallmark of glioma. Structural brain network provides an ef"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2109.01854","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2109.01854/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:13:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"lw3x5rFB3wNQF/FGHI94aP9a2V6tdrDxVG4EY+V8viTLRofXu+WvdhDYeicTsr85dCPyypyciZLvc97TcZhkDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-17T11:09:58.212267Z"},"content_sha256":"4b921afa16211f7a678af9448bf425b26e645914504e87118529038cf282fb5c","schema_version":"1.0","event_id":"sha256:4b921afa16211f7a678af9448bf425b26e645914504e87118529038cf282fb5c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ZQOQ32ZUVK23JOQWMJYVTCUVCY/bundle.json","state_url":"https://pith.science/pith/ZQOQ32ZUVK23JOQWMJYVTCUVCY/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ZQOQ32ZUVK23JOQWMJYVTCUVCY/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-17T11:09:58Z","links":{"resolver":"https://pith.science/pith/ZQOQ32ZUVK23JOQWMJYVTCUVCY","bundle":"https://pith.science/pith/ZQOQ32ZUVK23JOQWMJYVTCUVCY/bundle.json","state":"https://pith.science/pith/ZQOQ32ZUVK23JOQWMJYVTCUVCY/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ZQOQ32ZUVK23JOQWMJYVTCUVCY/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:ZQOQ32ZUVK23JOQWMJYVTCUVCY","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"cb74e93a6ee4fc8f63ab26eaba1e14887f1b2f18fc697db6c3fd3d2c2120247d","cross_cats_sorted":["cs.CV","q-bio.NC"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"eess.IV","submitted_at":"2021-09-04T12:19:33Z","title_canon_sha256":"6e1bd7ee50120708893b0c935bd164eb37c9bfb91cee39126f26ef5b71b7594c"},"schema_version":"1.0","source":{"id":"2109.01854","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2109.01854","created_at":"2026-07-05T03:13:05Z"},{"alias_kind":"arxiv_version","alias_value":"2109.01854v2","created_at":"2026-07-05T03:13:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2109.01854","created_at":"2026-07-05T03:13:05Z"},{"alias_kind":"pith_short_12","alias_value":"ZQOQ32ZUVK23","created_at":"2026-07-05T03:13:05Z"},{"alias_kind":"pith_short_16","alias_value":"ZQOQ32ZUVK23JOQW","created_at":"2026-07-05T03:13:05Z"},{"alias_kind":"pith_short_8","alias_value":"ZQOQ32ZU","created_at":"2026-07-05T03:13:05Z"}],"graph_snapshots":[{"event_id":"sha256:4b921afa16211f7a678af9448bf425b26e645914504e87118529038cf282fb5c","target":"graph","created_at":"2026-07-05T03:13:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2109.01854/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Glioma is a common malignant brain tumor with distinct survival among patients. The isocitrate dehydrogenase (IDH) gene mutation provides critical diagnostic and prognostic value for glioma. It is of crucial significance to non-invasively predict IDH mutation based on pre-treatment MRI. Machine learning/deep learning models show reasonable performance in predicting IDH mutation using MRI. However, most models neglect the systematic brain alterations caused by tumor invasion, where widespread infiltration along white matter tracts is a hallmark of glioma. Structural brain network provides an ef","authors_text":"Carola-Bibiane Sch\\\"onlieb, Chao Li, Stephen J. Price, Xi Chen, Yiran Wei, Yonghao Li","cross_cats":["cs.CV","q-bio.NC"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"eess.IV","submitted_at":"2021-09-04T12:19:33Z","title":"Predicting isocitrate dehydrogenase mutation status in glioma using structural brain networks and graph neural networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2109.01854","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e5f2c1f4754d4d38210900c5520526a7cf7636640bddadb28cb16bc4853d4fa9","target":"record","created_at":"2026-07-05T03:13:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"cb74e93a6ee4fc8f63ab26eaba1e14887f1b2f18fc697db6c3fd3d2c2120247d","cross_cats_sorted":["cs.CV","q-bio.NC"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"eess.IV","submitted_at":"2021-09-04T12:19:33Z","title_canon_sha256":"6e1bd7ee50120708893b0c935bd164eb37c9bfb91cee39126f26ef5b71b7594c"},"schema_version":"1.0","source":{"id":"2109.01854","kind":"arxiv","version":2}},"canonical_sha256":"cc1d0deb34aab5b4ba166271598a951609e7b52f4f1ee4ecebc8527c9d4f943b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"cc1d0deb34aab5b4ba166271598a951609e7b52f4f1ee4ecebc8527c9d4f943b","first_computed_at":"2026-07-05T03:13:05.892018Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:13:05.892018Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Ri/3StTIo0eRYhvI4ByJAnUP+s5DpSxkbHFeJPGZBa97HMMu1sfefUVhR3NP/bj3lnc3cqRqQuvsMP0PKSkMAg==","signature_status":"signed_v1","signed_at":"2026-07-05T03:13:05.892479Z","signed_message":"canonical_sha256_bytes"},"source_id":"2109.01854","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e5f2c1f4754d4d38210900c5520526a7cf7636640bddadb28cb16bc4853d4fa9","sha256:4b921afa16211f7a678af9448bf425b26e645914504e87118529038cf282fb5c"],"state_sha256":"9f3029db27bff859cebe4c3ec379a86a4eecc05bad0cbeec269eb5a1a5e285d2"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"sZjlZxdOSecnES3i8uc8WcitDK6Ocl3G26FsulvwLjeLZNREmr3I592jFvoetD3qGiPr9QoiPHfU4IperVIFAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-17T11:09:58.214420Z","bundle_sha256":"2f5e54b97972c23e8cb514e1de496a0a7553e6145f442c2c6bea08f3e766e532"}}