{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2012:ZRFYEP34H4R2ZFP4GGD5BTEGEI","short_pith_number":"pith:ZRFYEP34","canonical_record":{"source":{"id":"1210.5029","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2012-10-18T05:53:52Z","cross_cats_sorted":[],"title_canon_sha256":"082c6ae637175a992e622d31c9225d4c5affedcaa43d71442ccf126ba59b64eb","abstract_canon_sha256":"4f060567bc1267c1cb492a0122097b2babc813a56e7a89e9fe4bae2f652132e4"},"schema_version":"1.0"},"canonical_sha256":"cc4b823f7c3f23ac95fc3187d0cc862204b44efd6fbe0b406e7e062ecf0d9537","source":{"kind":"arxiv","id":"1210.5029","version":3},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1210.5029","created_at":"2026-05-18T03:06:03Z"},{"alias_kind":"arxiv_version","alias_value":"1210.5029v3","created_at":"2026-05-18T03:06:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1210.5029","created_at":"2026-05-18T03:06:03Z"},{"alias_kind":"pith_short_12","alias_value":"ZRFYEP34H4R2","created_at":"2026-05-18T12:27:30Z"},{"alias_kind":"pith_short_16","alias_value":"ZRFYEP34H4R2ZFP4","created_at":"2026-05-18T12:27:30Z"},{"alias_kind":"pith_short_8","alias_value":"ZRFYEP34","created_at":"2026-05-18T12:27:30Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2012:ZRFYEP34H4R2ZFP4GGD5BTEGEI","target":"record","payload":{"canonical_record":{"source":{"id":"1210.5029","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2012-10-18T05:53:52Z","cross_cats_sorted":[],"title_canon_sha256":"082c6ae637175a992e622d31c9225d4c5affedcaa43d71442ccf126ba59b64eb","abstract_canon_sha256":"4f060567bc1267c1cb492a0122097b2babc813a56e7a89e9fe4bae2f652132e4"},"schema_version":"1.0"},"canonical_sha256":"cc4b823f7c3f23ac95fc3187d0cc862204b44efd6fbe0b406e7e062ecf0d9537","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:06:03.548919Z","signature_b64":"+cn4NyQAKlebB/4e6kyXFvZyInLskZ7JdFZ7fbnDkDwchRolPqJclULUglqYe3HWW7XyXHj7HkbHIMBAHZN9Ag==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"cc4b823f7c3f23ac95fc3187d0cc862204b44efd6fbe0b406e7e062ecf0d9537","last_reissued_at":"2026-05-18T03:06:03.548299Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:06:03.548299Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1210.5029","source_version":3,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:06:03Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"gsvrDn3aAYgQUh2LWNcv2dJvNaQboOR2lFn5d24AelTRHwoPjWQZMAvv0nynowbNMi6LURqGWTZclEkVNNY7DQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T08:52:06.542120Z"},"content_sha256":"fac3a306df811c558a3fb634b26304539e4034e00c18aa8670e75c296818ad87","schema_version":"1.0","event_id":"sha256:fac3a306df811c558a3fb634b26304539e4034e00c18aa8670e75c296818ad87"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2012:ZRFYEP34H4R2ZFP4GGD5BTEGEI","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Bayesian clustering of replicated time-course gene expression data with weak signals","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.AP","authors_text":"Audrey Qiuyan Fu, Sarah J. Bray, Simon Tavar\\'e, Steven Russell","submitted_at":"2012-10-18T05:53:52Z","abstract_excerpt":"To identify novel dynamic patterns of gene expression, we develop a statistical method to cluster noisy measurements of gene expression collected from multiple replicates at multiple time points, with an unknown number of clusters. We propose a random-effects mixture model coupled with a Dirichlet-process prior for clustering. The mixture model formulation allows for probabilistic cluster assignments. The random-effects formulation allows for attributing the total variability in the data to the sources that are consistent with the experimental design, particularly when the noise level is high "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1210.5029","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:06:03Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0lCQWuCilVsHkuUB8X+QdVkp9FKSR3D5lbM7iwmb91cHi9CjNVlKFNvJ8CH6rTKOoPzn2sI9RJL04+nfhF46Bw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T08:52:06.542829Z"},"content_sha256":"1631f34f2f51c50a277e71bc0b3c0e65ca1df293c02eebddbf119152ca41e043","schema_version":"1.0","event_id":"sha256:1631f34f2f51c50a277e71bc0b3c0e65ca1df293c02eebddbf119152ca41e043"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ZRFYEP34H4R2ZFP4GGD5BTEGEI/bundle.json","state_url":"https://pith.science/pith/ZRFYEP34H4R2ZFP4GGD5BTEGEI/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ZRFYEP34H4R2ZFP4GGD5BTEGEI/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T08:52:06Z","links":{"resolver":"https://pith.science/pith/ZRFYEP34H4R2ZFP4GGD5BTEGEI","bundle":"https://pith.science/pith/ZRFYEP34H4R2ZFP4GGD5BTEGEI/bundle.json","state":"https://pith.science/pith/ZRFYEP34H4R2ZFP4GGD5BTEGEI/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ZRFYEP34H4R2ZFP4GGD5BTEGEI/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:ZRFYEP34H4R2ZFP4GGD5BTEGEI","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"4f060567bc1267c1cb492a0122097b2babc813a56e7a89e9fe4bae2f652132e4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2012-10-18T05:53:52Z","title_canon_sha256":"082c6ae637175a992e622d31c9225d4c5affedcaa43d71442ccf126ba59b64eb"},"schema_version":"1.0","source":{"id":"1210.5029","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1210.5029","created_at":"2026-05-18T03:06:03Z"},{"alias_kind":"arxiv_version","alias_value":"1210.5029v3","created_at":"2026-05-18T03:06:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1210.5029","created_at":"2026-05-18T03:06:03Z"},{"alias_kind":"pith_short_12","alias_value":"ZRFYEP34H4R2","created_at":"2026-05-18T12:27:30Z"},{"alias_kind":"pith_short_16","alias_value":"ZRFYEP34H4R2ZFP4","created_at":"2026-05-18T12:27:30Z"},{"alias_kind":"pith_short_8","alias_value":"ZRFYEP34","created_at":"2026-05-18T12:27:30Z"}],"graph_snapshots":[{"event_id":"sha256:1631f34f2f51c50a277e71bc0b3c0e65ca1df293c02eebddbf119152ca41e043","target":"graph","created_at":"2026-05-18T03:06:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"To identify novel dynamic patterns of gene expression, we develop a statistical method to cluster noisy measurements of gene expression collected from multiple replicates at multiple time points, with an unknown number of clusters. We propose a random-effects mixture model coupled with a Dirichlet-process prior for clustering. The mixture model formulation allows for probabilistic cluster assignments. The random-effects formulation allows for attributing the total variability in the data to the sources that are consistent with the experimental design, particularly when the noise level is high ","authors_text":"Audrey Qiuyan Fu, Sarah J. Bray, Simon Tavar\\'e, Steven Russell","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2012-10-18T05:53:52Z","title":"Bayesian clustering of replicated time-course gene expression data with weak signals"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1210.5029","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:fac3a306df811c558a3fb634b26304539e4034e00c18aa8670e75c296818ad87","target":"record","created_at":"2026-05-18T03:06:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"4f060567bc1267c1cb492a0122097b2babc813a56e7a89e9fe4bae2f652132e4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2012-10-18T05:53:52Z","title_canon_sha256":"082c6ae637175a992e622d31c9225d4c5affedcaa43d71442ccf126ba59b64eb"},"schema_version":"1.0","source":{"id":"1210.5029","kind":"arxiv","version":3}},"canonical_sha256":"cc4b823f7c3f23ac95fc3187d0cc862204b44efd6fbe0b406e7e062ecf0d9537","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"cc4b823f7c3f23ac95fc3187d0cc862204b44efd6fbe0b406e7e062ecf0d9537","first_computed_at":"2026-05-18T03:06:03.548299Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:06:03.548299Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"+cn4NyQAKlebB/4e6kyXFvZyInLskZ7JdFZ7fbnDkDwchRolPqJclULUglqYe3HWW7XyXHj7HkbHIMBAHZN9Ag==","signature_status":"signed_v1","signed_at":"2026-05-18T03:06:03.548919Z","signed_message":"canonical_sha256_bytes"},"source_id":"1210.5029","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:fac3a306df811c558a3fb634b26304539e4034e00c18aa8670e75c296818ad87","sha256:1631f34f2f51c50a277e71bc0b3c0e65ca1df293c02eebddbf119152ca41e043"],"state_sha256":"d87ec77c3cb1d1f7ec2f0c32ffbc1ff4405144d62b4001af34370811d4850045"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"SkhCUqM9gw8AFcxkxc7SIbCaZDA6gpBKlD1WL+/gFZ/uB6Kj1KjTuNu/odF1NJhF1wBHlXfIESKfAYII4fR0CQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T08:52:06.546488Z","bundle_sha256":"e1cfb6916bf80de923a44c7c549de98689e607b770c98838f4af767939a7c689"}}