{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2022:ZTIKDKK4WOTW3D2CL6FXFFNUDS","short_pith_number":"pith:ZTIKDKK4","canonical_record":{"source":{"id":"2208.11969","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2022-08-25T09:52:12Z","cross_cats_sorted":[],"title_canon_sha256":"039ea0e7a6007e99934bf2bf5384da2538daea9c05504f21db8081781d6a36fb","abstract_canon_sha256":"4ca0913b9447a876b4789610c7de4ec1327da86696570aaf624c3b30b9184d3b"},"schema_version":"1.0"},"canonical_sha256":"ccd0a1a95cb3a76d8f425f8b7295b41cab663c13745df9002693ad0eb52666d8","source":{"kind":"arxiv","id":"2208.11969","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2208.11969","created_at":"2026-07-05T10:58:11Z"},{"alias_kind":"arxiv_version","alias_value":"2208.11969v1","created_at":"2026-07-05T10:58:11Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2208.11969","created_at":"2026-07-05T10:58:11Z"},{"alias_kind":"pith_short_12","alias_value":"ZTIKDKK4WOTW","created_at":"2026-07-05T10:58:11Z"},{"alias_kind":"pith_short_16","alias_value":"ZTIKDKK4WOTW3D2C","created_at":"2026-07-05T10:58:11Z"},{"alias_kind":"pith_short_8","alias_value":"ZTIKDKK4","created_at":"2026-07-05T10:58:11Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2022:ZTIKDKK4WOTW3D2CL6FXFFNUDS","target":"record","payload":{"canonical_record":{"source":{"id":"2208.11969","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2022-08-25T09:52:12Z","cross_cats_sorted":[],"title_canon_sha256":"039ea0e7a6007e99934bf2bf5384da2538daea9c05504f21db8081781d6a36fb","abstract_canon_sha256":"4ca0913b9447a876b4789610c7de4ec1327da86696570aaf624c3b30b9184d3b"},"schema_version":"1.0"},"canonical_sha256":"ccd0a1a95cb3a76d8f425f8b7295b41cab663c13745df9002693ad0eb52666d8","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T10:58:11.986538Z","signature_b64":"zoHRUoZePJGboBJRhvXqBSKRwvhU2xucuiwMRvb6uVLUxlyPeA6F2SqOCDNaQ+s9qrBfzvmaLYplhYQyda/iBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ccd0a1a95cb3a76d8f425f8b7295b41cab663c13745df9002693ad0eb52666d8","last_reissued_at":"2026-07-05T10:58:11.986013Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T10:58:11.986013Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2208.11969","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:58:11Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"W6/fuXPgx7n6xoS4GrplaZax4cxHb30T0K0QPsirQ9whbVc5v2xAwZ/wiwafAe+PY3nQvsY5QYP9/2vRGX5rAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-18T16:40:29.698663Z"},"content_sha256":"3ed1851256b49effd96b32445e0fc4e31d647431e889ea6e85afc8f11a46ebeb","schema_version":"1.0","event_id":"sha256:3ed1851256b49effd96b32445e0fc4e31d647431e889ea6e85afc8f11a46ebeb"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2022:ZTIKDKK4WOTW3D2CL6FXFFNUDS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Mid-infrared photothermal single-live-cell imaging beyond video rate","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.optics","authors_text":"Genki Ishigane, Hiroyuki Shimada, Keiichiro Toda, Miu Tamamitsu, Takuro Ideguchi, Venkata Ramaiah Badarla","submitted_at":"2022-08-25T09:52:12Z","abstract_excerpt":"Advancement in mid-infrared (MIR) technology has led to promising biomedical applications of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR microscopy has been rarely used for live biological samples in an aqueous environment due to the lack of spatial resolution and the large water absorption background. Recently, mid-infrared photothermal (MIP) imaging has proven to be applicable to 2D and 3D single-cell imaging with high spatial resolution inherited from visible light. However, the maximum measurement rate has been limited to several frames/s, limiting its"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2208.11969","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2208.11969/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:58:11Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0KeMCefDrgMdOLmD6f4DtdlSo8GeLQxMfKePKOcsXIxPl4P//oZlRuXn0vP95h9mD+OsJVkErB/cqOJvKN8gCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-18T16:40:29.699263Z"},"content_sha256":"d5bd927c95f5c4f8d69ce5d7815ab5387c9eca2eb1ddb5b7f852fe2354d408d8","schema_version":"1.0","event_id":"sha256:d5bd927c95f5c4f8d69ce5d7815ab5387c9eca2eb1ddb5b7f852fe2354d408d8"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ZTIKDKK4WOTW3D2CL6FXFFNUDS/bundle.json","state_url":"https://pith.science/pith/ZTIKDKK4WOTW3D2CL6FXFFNUDS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ZTIKDKK4WOTW3D2CL6FXFFNUDS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-18T16:40:29Z","links":{"resolver":"https://pith.science/pith/ZTIKDKK4WOTW3D2CL6FXFFNUDS","bundle":"https://pith.science/pith/ZTIKDKK4WOTW3D2CL6FXFFNUDS/bundle.json","state":"https://pith.science/pith/ZTIKDKK4WOTW3D2CL6FXFFNUDS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ZTIKDKK4WOTW3D2CL6FXFFNUDS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:ZTIKDKK4WOTW3D2CL6FXFFNUDS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"4ca0913b9447a876b4789610c7de4ec1327da86696570aaf624c3b30b9184d3b","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2022-08-25T09:52:12Z","title_canon_sha256":"039ea0e7a6007e99934bf2bf5384da2538daea9c05504f21db8081781d6a36fb"},"schema_version":"1.0","source":{"id":"2208.11969","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2208.11969","created_at":"2026-07-05T10:58:11Z"},{"alias_kind":"arxiv_version","alias_value":"2208.11969v1","created_at":"2026-07-05T10:58:11Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2208.11969","created_at":"2026-07-05T10:58:11Z"},{"alias_kind":"pith_short_12","alias_value":"ZTIKDKK4WOTW","created_at":"2026-07-05T10:58:11Z"},{"alias_kind":"pith_short_16","alias_value":"ZTIKDKK4WOTW3D2C","created_at":"2026-07-05T10:58:11Z"},{"alias_kind":"pith_short_8","alias_value":"ZTIKDKK4","created_at":"2026-07-05T10:58:11Z"}],"graph_snapshots":[{"event_id":"sha256:d5bd927c95f5c4f8d69ce5d7815ab5387c9eca2eb1ddb5b7f852fe2354d408d8","target":"graph","created_at":"2026-07-05T10:58:11Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2208.11969/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Advancement in mid-infrared (MIR) technology has led to promising biomedical applications of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR microscopy has been rarely used for live biological samples in an aqueous environment due to the lack of spatial resolution and the large water absorption background. Recently, mid-infrared photothermal (MIP) imaging has proven to be applicable to 2D and 3D single-cell imaging with high spatial resolution inherited from visible light. However, the maximum measurement rate has been limited to several frames/s, limiting its","authors_text":"Genki Ishigane, Hiroyuki Shimada, Keiichiro Toda, Miu Tamamitsu, Takuro Ideguchi, Venkata Ramaiah Badarla","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2022-08-25T09:52:12Z","title":"Mid-infrared photothermal single-live-cell imaging beyond video rate"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2208.11969","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:3ed1851256b49effd96b32445e0fc4e31d647431e889ea6e85afc8f11a46ebeb","target":"record","created_at":"2026-07-05T10:58:11Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"4ca0913b9447a876b4789610c7de4ec1327da86696570aaf624c3b30b9184d3b","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2022-08-25T09:52:12Z","title_canon_sha256":"039ea0e7a6007e99934bf2bf5384da2538daea9c05504f21db8081781d6a36fb"},"schema_version":"1.0","source":{"id":"2208.11969","kind":"arxiv","version":1}},"canonical_sha256":"ccd0a1a95cb3a76d8f425f8b7295b41cab663c13745df9002693ad0eb52666d8","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ccd0a1a95cb3a76d8f425f8b7295b41cab663c13745df9002693ad0eb52666d8","first_computed_at":"2026-07-05T10:58:11.986013Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:58:11.986013Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"zoHRUoZePJGboBJRhvXqBSKRwvhU2xucuiwMRvb6uVLUxlyPeA6F2SqOCDNaQ+s9qrBfzvmaLYplhYQyda/iBA==","signature_status":"signed_v1","signed_at":"2026-07-05T10:58:11.986538Z","signed_message":"canonical_sha256_bytes"},"source_id":"2208.11969","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:3ed1851256b49effd96b32445e0fc4e31d647431e889ea6e85afc8f11a46ebeb","sha256:d5bd927c95f5c4f8d69ce5d7815ab5387c9eca2eb1ddb5b7f852fe2354d408d8"],"state_sha256":"076fcf23b3eb94097f4356748905177a3295072c0c1a6f14a5a68e3ff4a1baba"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"fhqds1RoU3soQNYGqcA8DwqmSThx/Ph2R1zC7c8qoLv30rXm1y2t6thGMv279ISjRmOYH8tEyRctU9/reBDACQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-18T16:40:29.704189Z","bundle_sha256":"05987a29c938711c237f48a6f327510ed43c0b363c0a929c193c6da5df2f6a11"}}