{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:ZXEGHTVTCRBHS4T6PR37QZMHEO","short_pith_number":"pith:ZXEGHTVT","canonical_record":{"source":{"id":"1809.04149","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.ins-det","submitted_at":"2018-09-08T08:56:46Z","cross_cats_sorted":["physics.optics"],"title_canon_sha256":"963a9f22c1b34149cbe113877fc242c9fc1da5ac3c22a28a343e91f8234be91e","abstract_canon_sha256":"f4926da1c3bfd93c5c73e218c79e588e84b607a41c1db8131e61e73e5fe8fc6b"},"schema_version":"1.0"},"canonical_sha256":"cdc863ceb3144279727e7c77f86587238b94187bb76fbd62321d0eed1bc318cd","source":{"kind":"arxiv","id":"1809.04149","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1809.04149","created_at":"2026-05-17T23:40:27Z"},{"alias_kind":"arxiv_version","alias_value":"1809.04149v2","created_at":"2026-05-17T23:40:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1809.04149","created_at":"2026-05-17T23:40:27Z"},{"alias_kind":"pith_short_12","alias_value":"ZXEGHTVTCRBH","created_at":"2026-05-18T12:33:07Z"},{"alias_kind":"pith_short_16","alias_value":"ZXEGHTVTCRBHS4T6","created_at":"2026-05-18T12:33:07Z"},{"alias_kind":"pith_short_8","alias_value":"ZXEGHTVT","created_at":"2026-05-18T12:33:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:ZXEGHTVTCRBHS4T6PR37QZMHEO","target":"record","payload":{"canonical_record":{"source":{"id":"1809.04149","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.ins-det","submitted_at":"2018-09-08T08:56:46Z","cross_cats_sorted":["physics.optics"],"title_canon_sha256":"963a9f22c1b34149cbe113877fc242c9fc1da5ac3c22a28a343e91f8234be91e","abstract_canon_sha256":"f4926da1c3bfd93c5c73e218c79e588e84b607a41c1db8131e61e73e5fe8fc6b"},"schema_version":"1.0"},"canonical_sha256":"cdc863ceb3144279727e7c77f86587238b94187bb76fbd62321d0eed1bc318cd","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:40:27.628524Z","signature_b64":"hVB0Cz9WaxGu7IxcmlZwJhjSHmkVZa4XPHxtIqFC0+3jKqRg7KsXKpac6GYrtjJtKMAIp/m19wCllyxyspufBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"cdc863ceb3144279727e7c77f86587238b94187bb76fbd62321d0eed1bc318cd","last_reissued_at":"2026-05-17T23:40:27.627934Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:40:27.627934Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1809.04149","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:40:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"dRReHwT+WbBD1kp6XJgHDwFyePmuNlW1LSbLMi58JdgnYgDLOaB3SFHjEi89qGKoxKU74ejnwNtKzL6bRk2uBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T17:47:34.569378Z"},"content_sha256":"c984e7abb7be64e55840051db07c9e5b07a91198ddfc99c0fdc8f021d50e6a0a","schema_version":"1.0","event_id":"sha256:c984e7abb7be64e55840051db07c9e5b07a91198ddfc99c0fdc8f021d50e6a0a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:ZXEGHTVTCRBHS4T6PR37QZMHEO","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Cram\\'er-Rao analysis of lifetime estimations in time-resolved fluorescence microscopy","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.optics"],"primary_cat":"physics.ins-det","authors_text":"Dorian Bouchet, Ignacio Izeddin, Valentina Krachmalnicoff","submitted_at":"2018-09-08T08:56:46Z","abstract_excerpt":"Measuring the lifetime of fluorescent emitters by time-correlated single photon counting (TCSPC) is a routine procedure in many research areas spanning from nanophotonics to biology. The precision of such measurement depends on the number of detected photons but also on the various sources of noise arising from the measurement process. Using Fisher information theory, we calculate the lower bound on the precision of lifetime estimations for mono-exponential and bi-exponential distributions. We analyse the dependence of the lifetime estimation precision on experimentally relevant parameters, in"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1809.04149","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:40:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"hc865QR9wR4XZNNCUfY5a6X/AST2CxfRq3KzqYr5tvnVhcNYK0eikISN3hQknW/4Wwd6x9bZeKtQHXmuWitBBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T17:47:34.569726Z"},"content_sha256":"b39f931b1d481c22dbcc7febabef7fc9d466bf3d7cb18359b760d698ade142bb","schema_version":"1.0","event_id":"sha256:b39f931b1d481c22dbcc7febabef7fc9d466bf3d7cb18359b760d698ade142bb"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ZXEGHTVTCRBHS4T6PR37QZMHEO/bundle.json","state_url":"https://pith.science/pith/ZXEGHTVTCRBHS4T6PR37QZMHEO/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ZXEGHTVTCRBHS4T6PR37QZMHEO/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-01T17:47:34Z","links":{"resolver":"https://pith.science/pith/ZXEGHTVTCRBHS4T6PR37QZMHEO","bundle":"https://pith.science/pith/ZXEGHTVTCRBHS4T6PR37QZMHEO/bundle.json","state":"https://pith.science/pith/ZXEGHTVTCRBHS4T6PR37QZMHEO/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ZXEGHTVTCRBHS4T6PR37QZMHEO/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:ZXEGHTVTCRBHS4T6PR37QZMHEO","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f4926da1c3bfd93c5c73e218c79e588e84b607a41c1db8131e61e73e5fe8fc6b","cross_cats_sorted":["physics.optics"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.ins-det","submitted_at":"2018-09-08T08:56:46Z","title_canon_sha256":"963a9f22c1b34149cbe113877fc242c9fc1da5ac3c22a28a343e91f8234be91e"},"schema_version":"1.0","source":{"id":"1809.04149","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1809.04149","created_at":"2026-05-17T23:40:27Z"},{"alias_kind":"arxiv_version","alias_value":"1809.04149v2","created_at":"2026-05-17T23:40:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1809.04149","created_at":"2026-05-17T23:40:27Z"},{"alias_kind":"pith_short_12","alias_value":"ZXEGHTVTCRBH","created_at":"2026-05-18T12:33:07Z"},{"alias_kind":"pith_short_16","alias_value":"ZXEGHTVTCRBHS4T6","created_at":"2026-05-18T12:33:07Z"},{"alias_kind":"pith_short_8","alias_value":"ZXEGHTVT","created_at":"2026-05-18T12:33:07Z"}],"graph_snapshots":[{"event_id":"sha256:b39f931b1d481c22dbcc7febabef7fc9d466bf3d7cb18359b760d698ade142bb","target":"graph","created_at":"2026-05-17T23:40:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Measuring the lifetime of fluorescent emitters by time-correlated single photon counting (TCSPC) is a routine procedure in many research areas spanning from nanophotonics to biology. The precision of such measurement depends on the number of detected photons but also on the various sources of noise arising from the measurement process. Using Fisher information theory, we calculate the lower bound on the precision of lifetime estimations for mono-exponential and bi-exponential distributions. We analyse the dependence of the lifetime estimation precision on experimentally relevant parameters, in","authors_text":"Dorian Bouchet, Ignacio Izeddin, Valentina Krachmalnicoff","cross_cats":["physics.optics"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.ins-det","submitted_at":"2018-09-08T08:56:46Z","title":"Cram\\'er-Rao analysis of lifetime estimations in time-resolved fluorescence microscopy"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1809.04149","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c984e7abb7be64e55840051db07c9e5b07a91198ddfc99c0fdc8f021d50e6a0a","target":"record","created_at":"2026-05-17T23:40:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f4926da1c3bfd93c5c73e218c79e588e84b607a41c1db8131e61e73e5fe8fc6b","cross_cats_sorted":["physics.optics"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.ins-det","submitted_at":"2018-09-08T08:56:46Z","title_canon_sha256":"963a9f22c1b34149cbe113877fc242c9fc1da5ac3c22a28a343e91f8234be91e"},"schema_version":"1.0","source":{"id":"1809.04149","kind":"arxiv","version":2}},"canonical_sha256":"cdc863ceb3144279727e7c77f86587238b94187bb76fbd62321d0eed1bc318cd","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"cdc863ceb3144279727e7c77f86587238b94187bb76fbd62321d0eed1bc318cd","first_computed_at":"2026-05-17T23:40:27.627934Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:40:27.627934Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"hVB0Cz9WaxGu7IxcmlZwJhjSHmkVZa4XPHxtIqFC0+3jKqRg7KsXKpac6GYrtjJtKMAIp/m19wCllyxyspufBg==","signature_status":"signed_v1","signed_at":"2026-05-17T23:40:27.628524Z","signed_message":"canonical_sha256_bytes"},"source_id":"1809.04149","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c984e7abb7be64e55840051db07c9e5b07a91198ddfc99c0fdc8f021d50e6a0a","sha256:b39f931b1d481c22dbcc7febabef7fc9d466bf3d7cb18359b760d698ade142bb"],"state_sha256":"c0d3d85f33a0e9879fe9faf8154c98bee07baaa42a0f9ddd1b819ba0c04575b9"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"N7zGE7uC+SkEztF1ANKxZ3FrQ/ZtzOoZNpDy+AbysnWi1U9jVV+LPiUvbS13McNwIpCIJNQEGc+IW/rpHrzxBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-01T17:47:34.571624Z","bundle_sha256":"cba1fa985efb8fd4615b6b1f270f65f3680d2da4a2cd88dc47cde2b2b75fa492"}}