{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:ZYBMAN23IVRQEJQKI7Z33FUMUZ","short_pith_number":"pith:ZYBMAN23","canonical_record":{"source":{"id":"1303.6374","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2013-03-26T03:15:32Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"45605c5ec2550ed4ce1faa40b13f82976e2781fa36087455acb406e81cc18979","abstract_canon_sha256":"f8b743443b330cc64b9f84055bf77410e6ae8d9250fe8ed9b35d6374817dc963"},"schema_version":"1.0"},"canonical_sha256":"ce02c0375b456302260a47f3bd968ca67366094f4f5077e348e078c6adca1f5d","source":{"kind":"arxiv","id":"1303.6374","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1303.6374","created_at":"2026-05-18T03:29:49Z"},{"alias_kind":"arxiv_version","alias_value":"1303.6374v1","created_at":"2026-05-18T03:29:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1303.6374","created_at":"2026-05-18T03:29:49Z"},{"alias_kind":"pith_short_12","alias_value":"ZYBMAN23IVRQ","created_at":"2026-05-18T12:28:09Z"},{"alias_kind":"pith_short_16","alias_value":"ZYBMAN23IVRQEJQK","created_at":"2026-05-18T12:28:09Z"},{"alias_kind":"pith_short_8","alias_value":"ZYBMAN23","created_at":"2026-05-18T12:28:09Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:ZYBMAN23IVRQEJQKI7Z33FUMUZ","target":"record","payload":{"canonical_record":{"source":{"id":"1303.6374","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2013-03-26T03:15:32Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"45605c5ec2550ed4ce1faa40b13f82976e2781fa36087455acb406e81cc18979","abstract_canon_sha256":"f8b743443b330cc64b9f84055bf77410e6ae8d9250fe8ed9b35d6374817dc963"},"schema_version":"1.0"},"canonical_sha256":"ce02c0375b456302260a47f3bd968ca67366094f4f5077e348e078c6adca1f5d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:29:49.613421Z","signature_b64":"G+Lv/dkNIxOtoTrnA2Kb0BF6kudHmRLLu5sOCmNktu6n9iMoXJ4LRem7I4ygHVJO6FcEnczeQfWuQCh4fwCdBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ce02c0375b456302260a47f3bd968ca67366094f4f5077e348e078c6adca1f5d","last_reissued_at":"2026-05-18T03:29:49.612788Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:29:49.612788Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1303.6374","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:29:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xCUFhNQvxynJHWCwy8QsrzTVTeV2I2yNoXDGuyL0JBbhVTjJVfipGU5TNW09QaB1lQNlvp4QZwSHdHMfwDOUCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T01:38:37.869361Z"},"content_sha256":"f905ab66853a452c0c7eba10e431f05cea6e08327807767d35efc4102f82661d","schema_version":"1.0","event_id":"sha256:f905ab66853a452c0c7eba10e431f05cea6e08327807767d35efc4102f82661d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:ZYBMAN23IVRQEJQKI7Z33FUMUZ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Stem-Like Adaptive Aneuploidy and Cancer Quasispecies","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN"],"primary_cat":"q-bio.CB","authors_text":"Daniele C. Struppa, Domenico Napoletani, Michele Signore","submitted_at":"2013-03-26T03:15:32Z","abstract_excerpt":"We analyze and reinterpret experimental evidence from the literature to argue for an ability of tumor cells to self-regulate their aneuploidy rate. We conjecture that this ability is mediated by a diversification factor that exploits molecular mechanisms common to embryo stem cells and, to a lesser extent, adult stem cells, that is eventually reactivated in tumor cells. Moreover, we propose a direct use of the quasispecies model to cancer cells based on their significant genomic instability (i.e. aneuploidy rate), by defining master sequences lengths as the sum of all copy numbers of physicall"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1303.6374","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:29:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"mcH/3sHDpSlAAKC5ICzeWqLfP2cGo6sAsFkdwcbj2QUqV0JMZDTKkqFEHn9SRYWe2cUl10pwJ0/Qox4D4edNBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T01:38:37.869867Z"},"content_sha256":"370560bc00c3e278a91ede146b53b1f74a3f3d32eccb036fb05fd5057613d135","schema_version":"1.0","event_id":"sha256:370560bc00c3e278a91ede146b53b1f74a3f3d32eccb036fb05fd5057613d135"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ZYBMAN23IVRQEJQKI7Z33FUMUZ/bundle.json","state_url":"https://pith.science/pith/ZYBMAN23IVRQEJQKI7Z33FUMUZ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ZYBMAN23IVRQEJQKI7Z33FUMUZ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-03T01:38:37Z","links":{"resolver":"https://pith.science/pith/ZYBMAN23IVRQEJQKI7Z33FUMUZ","bundle":"https://pith.science/pith/ZYBMAN23IVRQEJQKI7Z33FUMUZ/bundle.json","state":"https://pith.science/pith/ZYBMAN23IVRQEJQKI7Z33FUMUZ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ZYBMAN23IVRQEJQKI7Z33FUMUZ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:ZYBMAN23IVRQEJQKI7Z33FUMUZ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f8b743443b330cc64b9f84055bf77410e6ae8d9250fe8ed9b35d6374817dc963","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2013-03-26T03:15:32Z","title_canon_sha256":"45605c5ec2550ed4ce1faa40b13f82976e2781fa36087455acb406e81cc18979"},"schema_version":"1.0","source":{"id":"1303.6374","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1303.6374","created_at":"2026-05-18T03:29:49Z"},{"alias_kind":"arxiv_version","alias_value":"1303.6374v1","created_at":"2026-05-18T03:29:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1303.6374","created_at":"2026-05-18T03:29:49Z"},{"alias_kind":"pith_short_12","alias_value":"ZYBMAN23IVRQ","created_at":"2026-05-18T12:28:09Z"},{"alias_kind":"pith_short_16","alias_value":"ZYBMAN23IVRQEJQK","created_at":"2026-05-18T12:28:09Z"},{"alias_kind":"pith_short_8","alias_value":"ZYBMAN23","created_at":"2026-05-18T12:28:09Z"}],"graph_snapshots":[{"event_id":"sha256:370560bc00c3e278a91ede146b53b1f74a3f3d32eccb036fb05fd5057613d135","target":"graph","created_at":"2026-05-18T03:29:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We analyze and reinterpret experimental evidence from the literature to argue for an ability of tumor cells to self-regulate their aneuploidy rate. We conjecture that this ability is mediated by a diversification factor that exploits molecular mechanisms common to embryo stem cells and, to a lesser extent, adult stem cells, that is eventually reactivated in tumor cells. Moreover, we propose a direct use of the quasispecies model to cancer cells based on their significant genomic instability (i.e. aneuploidy rate), by defining master sequences lengths as the sum of all copy numbers of physicall","authors_text":"Daniele C. Struppa, Domenico Napoletani, Michele Signore","cross_cats":["q-bio.GN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2013-03-26T03:15:32Z","title":"Stem-Like Adaptive Aneuploidy and Cancer Quasispecies"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1303.6374","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f905ab66853a452c0c7eba10e431f05cea6e08327807767d35efc4102f82661d","target":"record","created_at":"2026-05-18T03:29:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f8b743443b330cc64b9f84055bf77410e6ae8d9250fe8ed9b35d6374817dc963","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2013-03-26T03:15:32Z","title_canon_sha256":"45605c5ec2550ed4ce1faa40b13f82976e2781fa36087455acb406e81cc18979"},"schema_version":"1.0","source":{"id":"1303.6374","kind":"arxiv","version":1}},"canonical_sha256":"ce02c0375b456302260a47f3bd968ca67366094f4f5077e348e078c6adca1f5d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ce02c0375b456302260a47f3bd968ca67366094f4f5077e348e078c6adca1f5d","first_computed_at":"2026-05-18T03:29:49.612788Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:29:49.612788Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"G+Lv/dkNIxOtoTrnA2Kb0BF6kudHmRLLu5sOCmNktu6n9iMoXJ4LRem7I4ygHVJO6FcEnczeQfWuQCh4fwCdBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T03:29:49.613421Z","signed_message":"canonical_sha256_bytes"},"source_id":"1303.6374","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f905ab66853a452c0c7eba10e431f05cea6e08327807767d35efc4102f82661d","sha256:370560bc00c3e278a91ede146b53b1f74a3f3d32eccb036fb05fd5057613d135"],"state_sha256":"44599e66d9fb2348a2600772f702489b2fa83917f079c4351935627e1b0962b4"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"alP4UrmPJw1bxLbz6jzer/XHXabdVe4fHnQufu7tiTWuKqoWUUdzeeEDgs+jufWD+lFZNOQM5+HkxhjMUDppBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-03T01:38:37.871838Z","bundle_sha256":"0fde139e21351f0e545c39e9e7dc71f3bb4c767dd4bf13ef2828f87ed9ce40a4"}}