{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:ZZM64BJSYYWOWLPBBJ6XA5OOZS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"028656517614fa2f8cf2686ed91a5a6808f3368f6d549723f915481deef4f94d","cross_cats_sorted":["stat.TH"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.ST","submitted_at":"2010-10-19T13:23:23Z","title_canon_sha256":"36af5662afdac8a8204eec933f00a9d03c1d9761a68caf9c5ca8cb80ead88570"},"schema_version":"1.0","source":{"id":"1010.3901","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1010.3901","created_at":"2026-05-18T04:39:07Z"},{"alias_kind":"arxiv_version","alias_value":"1010.3901v1","created_at":"2026-05-18T04:39:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1010.3901","created_at":"2026-05-18T04:39:07Z"},{"alias_kind":"pith_short_12","alias_value":"ZZM64BJSYYWO","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_16","alias_value":"ZZM64BJSYYWOWLPB","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_8","alias_value":"ZZM64BJS","created_at":"2026-05-18T12:26:18Z"}],"graph_snapshots":[{"event_id":"sha256:9335f35671962d7586710fd9a7ce6e27e3c7fd6da2dc4bed36d669c0369ac8b1","target":"graph","created_at":"2026-05-18T04:39:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Clinical trials are complex and usually involve multiple objectives such as controlling type I error rate, increasing power to detect treatment difference, assigning more patients to better treatment, and more. In literature, both response-adaptive randomization (RAR) procedures (by changing randomization procedure sequentially) and sequential monitoring (by changing analysis procedure sequentially) have been proposed to achieve these objectives to some degree. In this paper, we propose to sequentially monitor response-adaptive randomized clinical trial and study it's properties. We prove that","authors_text":"Feifang Hu, Hongjian Zhu","cross_cats":["stat.TH"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.ST","submitted_at":"2010-10-19T13:23:23Z","title":"Sequential monitoring of response-adaptive randomized clinical trials"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1010.3901","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:94a39d21ef95b660185778f644740285151c4dc064f1e1665f9b80ce42cec700","target":"record","created_at":"2026-05-18T04:39:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"028656517614fa2f8cf2686ed91a5a6808f3368f6d549723f915481deef4f94d","cross_cats_sorted":["stat.TH"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.ST","submitted_at":"2010-10-19T13:23:23Z","title_canon_sha256":"36af5662afdac8a8204eec933f00a9d03c1d9761a68caf9c5ca8cb80ead88570"},"schema_version":"1.0","source":{"id":"1010.3901","kind":"arxiv","version":1}},"canonical_sha256":"ce59ee0532c62ceb2de10a7d7075ceccb9d694d8e6b88614d65e407ae53ca313","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ce59ee0532c62ceb2de10a7d7075ceccb9d694d8e6b88614d65e407ae53ca313","first_computed_at":"2026-05-18T04:39:07.325927Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:39:07.325927Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"p4dzhsUrbfZt9OVInL+xVF3LTx6wWASQw11nVThS6eFLcQb4HCeI4Y3ESToyqQ75pE+XHsEbxxqysewD6wL3Aw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:39:07.326642Z","signed_message":"canonical_sha256_bytes"},"source_id":"1010.3901","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:94a39d21ef95b660185778f644740285151c4dc064f1e1665f9b80ce42cec700","sha256:9335f35671962d7586710fd9a7ce6e27e3c7fd6da2dc4bed36d669c0369ac8b1"],"state_sha256":"c41c45e91a71c01c3a39ddc6fc967364c4ad584654905bd4a14e602d929876bd"}