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arxiv 2412.16860 v1 pith:NJ4JIWDP submitted 2024-12-22 eess.IV cs.CV

Diffusion-Based Approaches in Medical Image Generation and Analysis

classification eess.IV cs.CV
keywords syntheticmodelsdatadatasetsmedicalcnnsdiffusiontrained
verification ladder T0 review T1 audit T2 compute T3 formal T4 reserved
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Data scarcity in medical imaging poses significant challenges due to privacy concerns. Diffusion models, a recent generative modeling technique, offer a potential solution by generating synthetic and realistic data. However, questions remain about the performance of convolutional neural network (CNN) models on original and synthetic datasets. If diffusion-generated samples can help CNN models perform comparably to those trained on original datasets, reliance on patient-specific data for training CNNs might be reduced. In this study, we investigated the effectiveness of diffusion models for generating synthetic medical images to train CNNs in three domains: Brain Tumor MRI, Acute Lymphoblastic Leukemia (ALL), and SARS-CoV-2 CT scans. A diffusion model was trained to generate synthetic datasets for each domain. Pre-trained CNN architectures were then trained on these synthetic datasets and evaluated on unseen real data. All three datasets achieved promising classification performance using CNNs trained on synthetic data. Local Interpretable Model-Agnostic Explanations (LIME) analysis revealed that the models focused on relevant image features for classification. This study demonstrates the potential of diffusion models to generate synthetic medical images for training CNNs in medical image analysis.

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  1. Wavelet-Fusion Diffusion Model for Multimodal Brain MRI Synthesis with Modality and Metadata Conditioning

    cs.CV 2026-05 unverdicted novelty 4.0

    WFDM uses wavelet-fusion VAE and conditional latent diffusion to generate synthetic multimodal brain MRI, claiming strongest distributional alignment among evaluated generators.