A cross-fitted one-step estimator that adjusts for a right-censored negative control outcome event time reduces variance by up to 27 percent in an HIV prevention trial, with multiple robustness and asymptotic efficiency.
Guideline on adjustment for baseline covariates in clinical tri- als, March 2015
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Improving the efficiency of infectious disease prevention trials using negative control outcome event times
A cross-fitted one-step estimator that adjusts for a right-censored negative control outcome event time reduces variance by up to 27 percent in an HIV prevention trial, with multiple robustness and asymptotic efficiency.