Phase separation of protein-RNA condensates is encoded by specific chemical interactions between individual dipeptides and nucleobases, with bases acting as tuners that dissolve, stabilize, or fluidize the assemblies.
Atomic structures of fus lc domain segments reveal bases for re- versible amyloid fibril formation.Nature structural & molecular biology, 25(4):341–346
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Deciphering the chemical grammar of protein-RNA condensates
Phase separation of protein-RNA condensates is encoded by specific chemical interactions between individual dipeptides and nucleobases, with bases acting as tuners that dissolve, stabilize, or fluidize the assemblies.