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SpReME: Sparse Regression for Multi-Environment Dynamic Systems

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abstract

Learning dynamical systems is a promising avenue for scientific discoveries. However, capturing the governing dynamics in multiple environments still remains a challenge: model-based approaches rely on the fidelity of assumptions made for a single environment, whereas data-driven approaches based on neural networks are often fragile on extrapolating into the future. In this work, we develop a method of sparse regression dubbed SpReME to discover the major dynamics that underlie multiple environments. Specifically, SpReME shares a sparse structure of ordinary differential equation (ODE) across different environments in common while allowing each environment to keep the coefficients of ODE terms independently. We demonstrate that the proposed model captures the correct dynamics from multiple environments over four different dynamic systems with improved prediction performance.

fields

q-bio.QM 1

years

2025 1

verdicts

CONDITIONAL 1

representative citing papers

Data-driven Discovery of Digital Twins in Biomedical Research

q-bio.QM · 2025-08-29 · conditional · novelty 2.0

Sparse regression, especially Bayesian approaches, generally outperform symbolic regression for ODE-based digital twin discovery in biology, though the evidence is qualitative and non-systematic.

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  • Data-driven Discovery of Digital Twins in Biomedical Research q-bio.QM · 2025-08-29 · conditional · none · ref 149 · internal anchor

    Sparse regression, especially Bayesian approaches, generally outperform symbolic regression for ODE-based digital twin discovery in biology, though the evidence is qualitative and non-systematic.