ContextFlow regularizes flow matching with a transition plausibility matrix built from local tissue organization and ligand-receptor patterns to produce statistically and biologically coherent trajectories from longitudinal spatial omics data.
Figures 3a and 3b illustrate the Excitatory–Inhibitory lineage switches present in these sampled couplings
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ContextFlow: Context-Aware Flow Matching For Trajectory Inference From Spatial Omics Data
ContextFlow regularizes flow matching with a transition plausibility matrix built from local tissue organization and ligand-receptor patterns to produce statistically and biologically coherent trajectories from longitudinal spatial omics data.