PRiMeFlow applies flow matching in gene expression space with a U-Net velocity field and pretraining-finetuning to model perturbation-induced heterogeneity, showing strong benchmark performance on PerturBench and the ARC Virtual Cell Challenge.
Toward ai-driven digital organism: Multiscale foundation models for predicting, simulating and programming biology at all levels.arXiv preprint arXiv:2412.06993
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PRiMeFlow: Capturing Complex Expression Heterogeneity in Perturbation Response Modelling
PRiMeFlow applies flow matching in gene expression space with a U-Net velocity field and pretraining-finetuning to model perturbation-induced heterogeneity, showing strong benchmark performance on PerturBench and the ARC Virtual Cell Challenge.