In a stochastic ribosome-traffic model with antibiotic-induced pauses and finite mRNA lifetimes, longer transcripts suffer disproportionately stronger translation inhibition, driven by collective ribosome dynamics rather than single-ribosome kinetics.
(11) to weight the average: T0 = Z tL 0 t F(t) dt Note that F (t) is the probability density function for the distribution of the first pausing time
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Paused in translation: A model for the transcript length-dependent impact of ribosome-targeting antibiotics
In a stochastic ribosome-traffic model with antibiotic-induced pauses and finite mRNA lifetimes, longer transcripts suffer disproportionately stronger translation inhibition, driven by collective ribosome dynamics rather than single-ribosome kinetics.