DoMinO reformulates discrete flow matching sampling as an MDP for unbiased RL fine-tuning with new TV regularizers, yielding better enhancer activity and naturalness on DNA design tasks.
Designing dna with tunable regulatory activity using score-entropy discrete diffusion.bioRxiv, pages 2024–05,
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Discrete Flow Matching Policy Optimization
DoMinO reformulates discrete flow matching sampling as an MDP for unbiased RL fine-tuning with new TV regularizers, yielding better enhancer activity and naturalness on DNA design tasks.