A random forest over tissue methylation blocks reaches moderate organ classification accuracy, but the claim to predict disease site conflates tissue type with disease state and the deconvolution validation uses the model's own training data.
Liquid Biopsy of Methylation Biomarkers in Cell-Free DNA
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A DNA Methylation Classification Model Predicts Organ and Disease Site
A random forest over tissue methylation blocks reaches moderate organ classification accuracy, but the claim to predict disease site conflates tissue type with disease state and the deconvolution validation uses the model's own training data.