Proposes a bias-corrected estimator for the second arm in a two-arm platform trial with non-concurrent controls and interim analysis on the first arm, using time-adjusted regression.
Unbiased estimation following a group sequential test.Biometrika, 86(1):71–78
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On the inclusion of non-concurrent controls in platform trials with an interim analysis
Proposes a bias-corrected estimator for the second arm in a two-arm platform trial with non-concurrent controls and interim analysis on the first arm, using time-adjusted regression.