A mathematical model shows radiotherapy protocol effectiveness and ranking depend on tumor oxygenation level and spatial geometry through phenotypic adaptation dynamics.
The linear-quadratic model is an appropriate methodology for determining iso- effective doses at large doses per fraction
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Oxygenation and spatial heterogeneity shape radiotherapy protocol ranking through phenotypic adaptation
A mathematical model shows radiotherapy protocol effectiveness and ranking depend on tumor oxygenation level and spatial geometry through phenotypic adaptation dynamics.