New causal estimands defined via stochastic time-dependent interventions and estimated with TMLE isolate the specific impact of a randomized treatment from concomitant medication use in diabetes cardiovascular outcomes trials.
Addendum on estimands and sensitivity analysis in clinical trials to the guideline on statistical principles for clinical trials E 9 ( R 1)
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Estimation of treatment effects in presence of differential use of post-randomization concomitant medication with time-to-event outcomes
New causal estimands defined via stochastic time-dependent interventions and estimated with TMLE isolate the specific impact of a randomized treatment from concomitant medication use in diabetes cardiovascular outcomes trials.