Masked-position MLM plus JEPA latent prediction outperforms MLM-only pretraining on 10-11 of 16 downstream tasks for 35M-150M protein models while JEPA alone fails.
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Bucket Masking improves protein fitness prediction by up to 14% over random masking by preferentially masking structurally coupled residue groups on four downstream tasks.
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ProteinJEPA: Latent prediction complements protein language models
Masked-position MLM plus JEPA latent prediction outperforms MLM-only pretraining on 10-11 of 16 downstream tasks for 35M-150M protein models while JEPA alone fails.
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Structure-Aware Masking for Protein Representation Learning
Bucket Masking improves protein fitness prediction by up to 14% over random masking by preferentially masking structurally coupled residue groups on four downstream tasks.