An integro-differential model with continuous phenotypic plasticity shows adaptive therapy outperforms continuous regimens by exploiting competition between sensitive and resistant clones, with high plasticity accelerating relapse under fixed therapy.
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.Cell, 141(1):69 – 80, 12 2009
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Modeling tumor cell heterogeneity and plasticity in adaptive therapy
An integro-differential model with continuous phenotypic plasticity shows adaptive therapy outperforms continuous regimens by exploiting competition between sensitive and resistant clones, with high plasticity accelerating relapse under fixed therapy.