A review arguing that identifiability analysis is a prerequisite for reliable parameter estimation and prediction in systems biology, and summarizing available computational tools.
An Introduction to the Calibration of Computer Models
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abstract
In the context of computer models, calibration is the process of estimating unknown simulator parameters from observational data. Calibration is variously referred to as model fitting, parameter estimation/inference, an inverse problem, and model tuning. The need for calibration occurs in most areas of science and engineering, and has been used to estimate hard to measure parameters in climate, cardiology, drug therapy response, hydrology, and many other disciplines. Although the statistical method used for calibration can vary substantially, the underlying approach is essentially the same and can be considered abstractly. In this survey, we review the decisions that need to be taken when calibrating a model, and discuss a range of computational methods that can be used to compute Bayesian posterior distributions.
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Think before you fit: parameter identifiability, sensitivity and uncertainty in systems biology models
A review arguing that identifiability analysis is a prerequisite for reliable parameter estimation and prediction in systems biology, and summarizing available computational tools.