CRISP uses query-driven MBAM reduction to turn large mechanistic QSP models into small fit-for-purpose models, demonstrated on coagulation and SHIV/bNAb therapy.
Quantitative Systems Pharmacology: an Exemplar Model-building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development
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A CRISP approach to QSP: XAI enabling fit-for-purpose models
CRISP uses query-driven MBAM reduction to turn large mechanistic QSP models into small fit-for-purpose models, demonstrated on coagulation and SHIV/bNAb therapy.