DNA-CRAFT combines class-conditioned discrete diffusion with conditional Monte Carlo tree guidance to generate regulatory DNA sequences that achieve higher predicted cell-type specificity and biological fidelity than prior diffusion, autoregressive, or optimization baselines.
URL https://www.nature.com/articles/ s12276-024-01233-y
1 Pith paper cite this work. Polarity classification is still indexing.
1
Pith paper citing it
fields
q-bio.GN 1years
2026 1verdicts
UNVERDICTED 1representative citing papers
citing papers explorer
-
Conditional Monte Carlo Tree Diffusion for Designing Cell-Type-Specific and Biologically Faithful Regulatory DNA
DNA-CRAFT combines class-conditioned discrete diffusion with conditional Monte Carlo tree guidance to generate regulatory DNA sequences that achieve higher predicted cell-type specificity and biological fidelity than prior diffusion, autoregressive, or optimization baselines.