Intervention-aware distillation transfers mechanistic knowledge from perturbational transcriptomics to imaging phenomics for improved one-shot transfer to unseen drugs and target gene discovery.
Three million images and morphological pro- files of cells treated with matched chemical and genetic pertur- bations.Nature Methods, 21(6):1114–1121, 2024
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Intervention-Aware Multiscale Representation Learning from Imaging Phenomics and Perturbation Transcriptomics
Intervention-aware distillation transfers mechanistic knowledge from perturbational transcriptomics to imaging phenomics for improved one-shot transfer to unseen drugs and target gene discovery.