Neutralization titers follow Gumbel distributions indicating influenza polyclonal responses are either collective or dominated by few strong binders, captured quantitatively by an equilibrium binding model.
(2021) Comprehensive mapping of mutations in the sars-cov-2 receptor-binding domain that affect recognition by polyclonal human plasma antibod- ies.Cell Host & Microbe29:463–476.e6
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Neutralization titers reveal the structure of polyclonal antibody responses
Neutralization titers follow Gumbel distributions indicating influenza polyclonal responses are either collective or dominated by few strong binders, captured quantitatively by an equilibrium binding model.