Denser platelet plugs accelerate fibrin gelation at the periphery under flow, while looser plugs enable deeper fibrinogen access leading to wall-initiated gelation, indicating a tradeoff between rapid sealing and stable clot formation.
Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network
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Platelet plug microstructure and flow modulate fibrin gelation dynamics: Insights from computational simulations
Denser platelet plugs accelerate fibrin gelation at the periphery under flow, while looser plugs enable deeper fibrinogen access leading to wall-initiated gelation, indicating a tradeoff between rapid sealing and stable clot formation.