Chem2Gen-Bench is a new benchmark and evaluation framework for measuring alignment between chemical and genetic perturbation responses in matched cell-target contexts using retrieval, similarity, and embedding comparisons.
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cs.LG 2years
2026 2verdicts
UNVERDICTED 2representative citing papers
K-nearest neighbor from a knowledge graph beats most methods on out-of-distribution transcriptomic perturbation prediction, and an RL-trained reasoning LLM matches SOTA on Replogle et al. (2022) cell lines while improving downstream differential expression prediction.
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Chem2Gen-Bench: Benchmarking Chemical-to-Genetic Translation in Perturbation Response Space
Chem2Gen-Bench is a new benchmark and evaluation framework for measuring alignment between chemical and genetic perturbation responses in matched cell-target contexts using retrieval, similarity, and embedding comparisons.
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Knowledge Graphs and Reasoning LLMs for Finding Simple Yet Effective Transcriptomic Perturbation Predictors
K-nearest neighbor from a knowledge graph beats most methods on out-of-distribution transcriptomic perturbation prediction, and an RL-trained reasoning LLM matches SOTA on Replogle et al. (2022) cell lines while improving downstream differential expression prediction.