DeepFilters jointly optimizes a parameterized pupil filter and digital reconstruction network via a calibrated differentiable forward model with empirical scattering kernels to extend PSF depth from 16 to over 400 microns in clear media and recover signals beyond 120 microns in tissues.
Extended two-photon microscopy in live samples with Bessel beams: steadier focus, faster volume scans, and simpler stereoscopic imaging,
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2026 1verdicts
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DeepFilters: Scattering-Aware Pupil Engineering with Learned Digital Filter Reconstruction for Extended Depth of Field Microscopy
DeepFilters jointly optimizes a parameterized pupil filter and digital reconstruction network via a calibrated differentiable forward model with empirical scattering kernels to extend PSF depth from 16 to over 400 microns in clear media and recover signals beyond 120 microns in tissues.