A new closed-book, sequence-only benchmark, EpiBench, measures epitope reasoning in LLMs and finds them near chance on residue-level localization and escape assessment, with only coarse region-level signal.
Proteinglue multi-task benchmark suite for self-supervised protein modeling.Scientific Reports, 12(1):16047, 2022
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EpiBench: Can LLMs Understand Epitopes for Antibody Drug Discovery?
A new closed-book, sequence-only benchmark, EpiBench, measures epitope reasoning in LLMs and finds them near chance on residue-level localization and escape assessment, with only coarse region-level signal.