Non-coplanar 4π planning substantially lowers pelvic bone marrow doses in cervical cancer, but the headline 23% hematologic toxicity reduction is a model extrapolation that loses statistical significance when model training uncertainty is included.
External beam radiation therapy (EBRT), often delivered in combination with brachytherapy and chemotherapy, is a cornerstone in the management of locally advanced disease(2)
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4$\pi$ Planning for the Reduction of Predicted Hematologic Toxicity Risk in Cervical Cancer Radiotherapy
Non-coplanar 4π planning substantially lowers pelvic bone marrow doses in cervical cancer, but the headline 23% hematologic toxicity reduction is a model extrapolation that loses statistical significance when model training uncertainty is included.