A two-stage intra-patient curve-free Bayesian decision-theoretic design for dose escalation under nonincreasing cycle-specific toxicity.
be the probability of a DLT at dose combination (๐,๐), where ๐โ{1,โฆ,๐ผ} and ๐โ{1,โฆ,๐ฝ}. Let ๐ฆ!
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TWICEBEE: A Two-stage Intra-patient Curve-free Bayesian Decision-Theoretic Dose Escalation Design
A two-stage intra-patient curve-free Bayesian decision-theoretic design for dose escalation under nonincreasing cycle-specific toxicity.