Every bidirectional mass-action chemical system is the reduction of a closed, detailed-balanced system obtained by adding substances and reactions.
Feinberg, Necessary and sufficient conditions for detailed balancing in mass action systems of arbitrary complexity, Chemical Engineering Science, 44 (1989), pp
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The detailed balance property and chemical systems out of equilibrium
Every bidirectional mass-action chemical system is the reduction of a closed, detailed-balanced system obtained by adding substances and reactions.