Ctrl-DNA applies constrained reinforcement learning to a genomic language model, generating promoter and enhancer sequences whose predicted activity is high in a target cell type and suppressed in off-target cell types.
Designing cell-type-specific promoter sequences using conservative model-based optimization
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Ctrl-DNA: Controllable Cell-Type-Specific Regulatory DNA Design via Constrained RL
Ctrl-DNA applies constrained reinforcement learning to a genomic language model, generating promoter and enhancer sequences whose predicted activity is high in a target cell type and suppressed in off-target cell types.