Time-varying Cox models and marginal structural models on ABCD data link higher impulsivity, lower parental monitoring, and nicotine PRS to earlier substance initiation, suggesting causal roles for these factors.
Multivariate genome- wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
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Time-Varying Environmental and Polygenic Predictors of Substance Use Initiation in Youth: A Survival and Causal Modeling Study in the ABCD Cohort
Time-varying Cox models and marginal structural models on ABCD data link higher impulsivity, lower parental monitoring, and nicotine PRS to earlier substance initiation, suggesting causal roles for these factors.