bioETH-PRS performs private polygenic risk score computation entirely in the encrypted domain on an fhEVM blockchain using TFHE, a three-step fixed-point quantization, and a four-contract architecture with an on-chain noisy output oracle.
Lambert and Laurent Gil and Simon Jupp and Scott C
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bioETH-PRS: Confidential Polygenic Risk Scoring without a Trusted Evaluator via Fully Homomorphic Encryption on a Programmable Blockchain
bioETH-PRS performs private polygenic risk score computation entirely in the encrypted domain on an fhEVM blockchain using TFHE, a three-step fixed-point quantization, and a four-contract architecture with an on-chain noisy output oracle.