Pauli Correlation Encoding with a trained problem-aware decoder achieves 75-100% near-optimal recovery on mRNA QUBO instances up to 152 variables and matches or exceeds simulator performance on IBM Heron processors for 694-745 variable cases.
To- wards large-scale quantum optimization solvers with few qubits,
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Pauli Correlation Encoding for mRNA Secondary Structure Prediction: Problem-Aware Decoding for Dense-Constraint QUBOs
Pauli Correlation Encoding with a trained problem-aware decoder achieves 75-100% near-optimal recovery on mRNA QUBO instances up to 152 variables and matches or exceeds simulator performance on IBM Heron processors for 694-745 variable cases.