In a coarse-grained polymer replication model treated as a channel, mutual information per monomer depends only on template specificity in the accurate regime, with information-energy efficiency optimized at an alphabet size determined by per-monomer free energy and DNA's observed energy placing it远
Dissipation-error tradeoff in proofreading.BioSystems, 11(2-3):85–91
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Information-to-energy trade-offs and the optimal alphabet of polymer replication
In a coarse-grained polymer replication model treated as a channel, mutual information per monomer depends only on template specificity in the accurate regime, with information-energy efficiency optimized at an alphabet size determined by per-monomer free energy and DNA's observed energy placing it远