A closed-loop design framework that uses chemical fragments to guide a large language model in generating novel, high-affinity lead compounds outperformed existing de novo drug design methods.
Empower Large Language Model to Perform Better on Industrial Domain-Specific Question Answering
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abstract
Large Language Model (LLM) has gained popularity and achieved remarkable results in open-domain tasks, but its performance in real industrial domain-specific scenarios is average due to its lack of specific domain knowledge. This issue has attracted widespread attention, but there are few relevant benchmarks available. In this paper, we provide a benchmark Question Answering (QA) dataset named MSQA, centered around Microsoft products and IT technical problems encountered by customers. This dataset contains industry cloud-specific QA knowledge, an area not extensively covered in general LLMs, making it well-suited for evaluating methods aiming to enhance LLMs' domain-specific capabilities. In addition, we propose a new model interaction paradigm that can empower LLM to achieve better performance on domain-specific tasks where it is not proficient. Extensive experiments demonstrate that the approach following our method outperforms the commonly used LLM with retrieval methods. We make our source code and sample data available at: https://aka.ms/Microsoft_QA.
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A Collaborative Framework Integrating Large Language Model and Chemical Fragment Space: Mutual Inspiration for Lead Design
A closed-loop design framework that uses chemical fragments to guide a large language model in generating novel, high-affinity lead compounds outperformed existing de novo drug design methods.