mRNAutilus generates full-length therapeutic mRNAs via diffusion models and multi-objective guidance, achieving over 400-fold expression gains for luciferase and outperforming baselines for Spike and other targets in zero-shot tests.
Available: https://arxiv.org/abs/2502.13785
2 Pith papers cite this work. Polarity classification is still indexing.
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Pith papers citing it
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2026 2verdicts
UNVERDICTED 2representative citing papers
BERT-GA framework optimizes therapeutic mRNA sequences to CAI 0.73-0.74, tAI 0.63-0.64, balanced MFE around -350 kcal/mol, and reduced CpG/UpA motifs, claiming better equilibrium than Linear Design or BiLSTM-CRF.
citing papers explorer
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mRNAutilus: Multi-Objective-Guided Discrete Generation of mRNA with Optimized Therapeutic Properties
mRNAutilus generates full-length therapeutic mRNAs via diffusion models and multi-objective guidance, achieving over 400-fold expression gains for luciferase and outperforming baselines for Spike and other targets in zero-shot tests.
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An Evolutionary Approach for Designing Stable and Highly Expressible Low-Immunogenicity Therapeutic mRNA Sequences
BERT-GA framework optimizes therapeutic mRNA sequences to CAI 0.73-0.74, tAI 0.63-0.64, balanced MFE around -350 kcal/mol, and reduced CpG/UpA motifs, claiming better equilibrium than Linear Design or BiLSTM-CRF.