A multi-stage framework with prompt calibration, rule-based filtering, semantic checks, judge LLM review, and predictive validation enables trustworthy LLM extraction of substance use disorder diagnoses from nearly 920,000 clinical notes, achieving F1 of 0.80 and superior care-engagement prediction.
Automated detection of substance use information from electronic health records for a pediatric population
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A Multi-Stage Validation Framework for Trustworthy Large-scale Clinical Information Extraction using Large Language Models
A multi-stage framework with prompt calibration, rule-based filtering, semantic checks, judge LLM review, and predictive validation enables trustworthy LLM extraction of substance use disorder diagnoses from nearly 920,000 clinical notes, achieving F1 of 0.80 and superior care-engagement prediction.