PCA and k-means on NHANES data identified four reproductive phenotypes in U.S. women aged 20-44, with one fragile subgroup showing 77.5% early multimorbidity prevalence; XGBoost improved discrimination over logistic regression but had worse calibration.
National Health and Nutrition Examination Survey, 2017 –March 2020 prepandemic file: sample design, estimation, and analytic guidelines
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AI-Derived Reproductive Phenotypes and Explainable ML for Concurrent Early Multimorbidity in U.S. Women: NHANES 2017-March 2020
PCA and k-means on NHANES data identified four reproductive phenotypes in U.S. women aged 20-44, with one fragile subgroup showing 77.5% early multimorbidity prevalence; XGBoost improved discrimination over logistic regression but had worse calibration.