A conductance-based network model shows that the fraction of inhibitory synaptic conductance driving chloride influx organizes seizures into distinct pre-ictal, tonic, and clonic stages with characteristic dynamics.
Chloride regulation: a dynamic equilibrium crucial for synaptic inhibition.Neuron, 89(6):1157–1172
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Role of chloride concentration in modulating seizure transitions in excitatory and inhibitory networks
A conductance-based network model shows that the fraction of inhibitory synaptic conductance driving chloride influx organizes seizures into distinct pre-ictal, tonic, and clonic stages with characteristic dynamics.