A large benchmark finds traditional imputation methods for scRNA-seq data generally outperform deep learning ones, but numerical recovery does not reliably improve biological downstream analyses and no method wins across all settings.
Nature Communications12(1), 1882 (2021) https://doi
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scHelix uses explicit gene-level partitioning into Anchors and Variants plus an asymmetric Align-Refine-Fuse dual-stream architecture to improve batch correction in scRNA-seq without over-correcting biological signals.
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A Large-Scale Comparative Analysis of Imputation Methods for Single-Cell RNA Sequencing Data
A large benchmark finds traditional imputation methods for scRNA-seq data generally outperform deep learning ones, but numerical recovery does not reliably improve biological downstream analyses and no method wins across all settings.
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scHelix: Asymmetric Dual-Stream Integration via Explicit Gene-Level Disentanglement
scHelix uses explicit gene-level partitioning into Anchors and Variants plus an asymmetric Align-Refine-Fuse dual-stream architecture to improve batch correction in scRNA-seq without over-correcting biological signals.