CFT Design is a new framework for optimizing nonequilibrium flow networks in molecular machines, applied to faster motors, balanced proofreaders, and better enzyme inhibitors.
However, the irreversible catalytic sink at state 1 (ES→E) induces a steady-state compensatory backflow,J leak
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Nonequilibrium Theory for Molecular Machine Design
CFT Design is a new framework for optimizing nonequilibrium flow networks in molecular machines, applied to faster motors, balanced proofreaders, and better enzyme inhibitors.