CDM amortizes SMC inference for reward-tilted discrete diffusion by training a parameterized twist function on contrastive samples with closed-form kernels.
Machine-guided design of synthetic cell type-specific cis-regulatory elements.bioRxiv, 2023
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Contrastive Distribution Matching for Amortized Sequential Monte Carlo in Discrete Diffusion
CDM amortizes SMC inference for reward-tilted discrete diffusion by training a parameterized twist function on contrastive samples with closed-form kernels.