A categorical preorder on trial tallies reveals a new monotonicity flaw in the 3+3 dose-escalation design and yields right Kan and Galois extensions that support titration.
Skolnik, Jeffrey S
1 Pith paper cite this work, alongside 267 external citations. Polarity classification is still indexing.
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Dose-Escalation Trial Protocols that Extend Naturally to Admit Titration
A categorical preorder on trial tallies reveals a new monotonicity flaw in the 3+3 dose-escalation design and yields right Kan and Galois extensions that support titration.